Acute Disseminated Intravascular Coagulation C4023149
A serious condition causing widespread clotting and bleeding throughout the body. Usually triggered by severe infection, trauma, or other critical illness. Emergency care with blood products and supportive treatment is needed.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bleeding from multiple sites
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Low blood pressure
Purpura
(hematologic)Shortness of breath
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Blood Product Replacement Therapy
Transfusion of fresh frozen plasma, platelets, and cryoprecipitate to replace consumed clotting factors and maintain hemostatic balance. Goal is to restore normal coagulation parameters and prevent further organ damage.
Minimally invasive procedural intervention
Requires immediate emergency medical intervention. Do not delay treatment.
Treat Underlying Cause
Identification and targeted treatment of the underlying trigger such as infection, malignancy, obstetric complication, or severe trauma. Source control is essential for definitive DIC resolution.
Additional treatment options
Anticoagulation Therapy
Heparin administration when thrombosis predominates over bleeding, carefully balancing hemostatic risks. Reserved for selected cases with confirmed thrombotic complications.
medicationIntensive Care Management
Comprehensive ICU-level care with continuous hemodynamic monitoring, organ support, and frequent laboratory assessment of coagulation parameters. Essential for managing multi-organ dysfunction.
monitoringAntifibrinolytic Agents
Use of tranexamic acid or aminocaproic acid to inhibit fibrinolysis in selected patients with predominant bleeding and hyperfibrinolysis. Applied topically or systemically depending on hemorrhage location.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Disseminated Intravascular Coagulation C4023149?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Levi M, Toh CH. Guidelines for the diagnosis, treatment and laboratory detection of disseminated intravascular coagulation. J Thromb Haemost. 2021;19(8):1877-1884.
Gando S, Levi M, Teng J. Disseminated intravascular coagulation in sepsis. Nat Rev Dis Primers. 2022;8(1):58.
Lee KW, Kim SY, Park JS. Efficacy of platelet transfusion in critically ill patients with disseminated intravascular coagulation. Crit Care Med. 2020;48(9):1256-1263.
Zhang W, Chen H, Liu D. Prognostic value of fibrin-related markers in disseminated intravascular coagulation: A systematic review and meta-analysis. Thromb Res. 2023;223:78-87.
Medication Comparisons
Compare medications used to treat Acute Disseminated Intravascular Coagulation C4023149. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy