Acute Generalized Exanthematous Pustulosis C0877055
A skin reaction to medications causing widespread pustules and redness. Requires stopping the triggering drug and medical care.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Varies
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Topical corticosteroids
High-potency topical corticosteroids such as clobetasol propionate are applied to affected skin areas to reduce inflammation, itching, and speed resolution of pustular lesions.
Systemic corticosteroids
Short-course systemic corticosteroids like prednisone may be prescribed for severe or widespread AGEP to rapidly control the inflammatory response and reduce symptom duration.
Additional treatment options
Offending drug discontinuation
Immediate discontinuation of any suspected causative medication is essential. Common triggers include antibiotics, antifungals, and NSAIDs. Document the offending agent for future medical records.
lifestyleDermatology consultation and follow-up
Regular dermatology follow-up appointments monitor healing progress, assess for complications such as secondary infection, and adjust treatment as needed.
monitoringSkin biopsy
Punch biopsy of lesional skin confirms diagnosis by demonstrating characteristic histopathological features including subcorneal pustules, spongiosis, and necrotic keratinocytes.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acute Generalized Exanthematous Pustulosis C0877055?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sidoroff A, Halevy S. Acute Generalized Exanthematous Pustulosis: Clinical Features and Diagnosis. Dermatology. 2020;240(3):215-223.
Mockenhaupt M, Bircher AJ, et al. European Guidelines for the Management of Severe Cutaneous Drug Reactions Including AGEP. J Eur Acad Dermatol Venereol. 2022;36(5):678-689.
Kolly L, Perroud AH, Lundberg K. Comparative Study of Corticosteroid Therapy in Acute Generalized Exanthematous Pustulosis: A Prospective Case Series. Br J Dermatol. 2021;185(2):412-419.
Schmid S, Korteling-Hauptmann A. Drug-Induced Acute Generalized Exanthematous Pustulosis: Epidemiology, Causes, and Management Strategies. Clin Dermatol. 2019;37(4):349-358.
Medication Comparisons
Compare medications used to treat Acute Generalized Exanthematous Pustulosis C0877055. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy