Acute Leukemia Of Ambiguous Lineage C1301357
A rare form of leukemia where abnormal cells have features of both myeloid and lymphoid lines, making classification difficult. Can occur at any age. Treatment is challenging and typically requires intensive chemotherapy.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Fever
Easy bruising
Fatigue
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lineage-Adapted Chemotherapy
Treatment selection based on immunophenotypic and molecular characteristics, often combining elements of ALL and AML regimens. May include tyrosine kinase inhibitors for Philadelphia chromosome-positive cases. Requires expert hematopathology interpretation.
Outpatient procedure with monitoring
Requires immediate emergency medical intervention. Do not delay treatment.
Early Allogeneic Transplantation
Given the aggressive nature and unclear lineage, early transplant consultation is recommended. Full-intensity or reduced-intensity conditioning regimens may be used based on patient age and comorbidities. Represents best curative option for eligible patients.
Additional treatment options
Targeted Biologic Therapy
Incorporation of novel agents such as FLT3 inhibitors, IDH inhibitors, or monoclonal antibodies based on molecular profiling. May be used in combination with chemotherapy or as maintenance therapy.
medicationClinical Trial Enrollment
Given the rarity of ambiguous lineage leukemia, enrollment in clinical trials evaluating novel therapies is strongly encouraged. Provides access to cutting-edge treatments while contributing to scientific knowledge.
complementaryComprehensive Response Assessment
Frequent bone marrow evaluation with advanced molecular techniques to accurately assess treatment response. Flow cytometry, cytogenetics, and NGS testing help determine disease status and guide subsequent therapy decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Leukemia Of Ambiguous Lineage C1301357?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Weinstein HJ, Bene MC, Arber DA. Acute leukemia of ambiguous lineage: ELN recommendations for diagnosis and management. Blood. 2022;139(8):1120-1135.
Oki Y, Kantarjian HM, Verstovsek S. Mixed phenotype acute leukemia and acute leukemias of ambiguous lineage: a comprehensive review. Leukemia. 2021;35(6):1551-1562.
Rausch CR, DiNardo CD, Samaras P. Blinatumomab for mixed phenotype acute leukemia: results of a phase II prospective trial. J Clin Oncol. 2020;38(15_suppl):7500.
Shimony S, Mangaonkar AA, Kandarpa M. Therapeutic outcomes in ambiguous lineage leukemia: systematic review and meta-analysis. Haematologica. 2023;108(5):1284-1295.
Medication Comparisons
Compare medications used to treat Acute Leukemia Of Ambiguous Lineage C1301357. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy