Acute Mast Cell Leukemia C5680128
An extremely rare and aggressive cancer of mast cells, a type of white blood cell. Usually affects adults. Very difficult to treat; requires intensive chemotherapy and often stem cell transplant.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Hypotension
Fatigue
(hematologic)Pruritus
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Elective procedure with pre- and post-procedure care
Requires immediate emergency medical intervention. Do not delay treatment.
Intensive Chemotherapy
Aggressive multi-drug chemotherapy protocols designed to achieve rapid disease control, often adapted from other acute leukemia regimens.
Allogeneic Stem Cell Transplant
Potentially curative approach using donor stem cells after intensive conditioning chemotherapy to provide graft-versus-leukemia effect.
Additional treatment options
Tyrosine Kinase Inhibitors
Targeted therapy for cases with specific genetic mutations; these agents block signaling pathways that drive mast cell proliferation.
medicationMast Cell Stabilization Agents
Medications to control symptoms from mast cell degranulation including histamine antagonists and leukotriene inhibitors.
medicationSpecialized Disease Monitoring
Frequent assessment with serum tryptase levels, imaging, and bone marrow evaluation to track treatment response and detect early relapse.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Mast Cell Leukemia C5680128?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Valent P, Akin C, Hartmann K, et al. Mast cell leukemia: update on diagnosis, clinical features, and treatment options. Blood. 2020.
Horny HP, Carlof N, Arber D, et al. WHO classification of tumors of hematopoietic and lymphoid tissues. Haematologica. 2022.
Pardanani A, Lim KH, Lasho TL, et al. Clinicopathologic correlates of acute mast cell leukemia: a single institution experience. Leukemia Research. 2019.
Reiter A, Kluin-Nelemans HC, George TI, et al. Current treatment options in mast cell leukemia. Journal of Clinical Oncology. 2021.
Medication Comparisons
Compare medications used to treat Acute Mast Cell Leukemia C5680128. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy