Acute Megakaryoblastic Leukemia C0023462
A rare blood cancer where immature megakaryocyte cells build up in bone marrow and blood. More common in children. Treated with intensive chemotherapy and sometimes stem cell transplant.
Key facts at a glance
- ICD-10
- C94.20, C94.21, C94.22
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Bleeding
Fatigue
(hematologic)Pallor
(hematologic)Hepatosplenomegaly
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Minimally invasive procedural intervention
Requires immediate emergency medical intervention. Do not delay treatment.
Intensive Chemotherapy Regimens
High-dose combination chemotherapy designed to achieve remission, with specific protocols depending on patient age and underlying etiology such as Down syndrome.
Hematopoietic Stem Cell Transplant
Curative approach involving intensive chemotherapy followed by stem cell rescue, particularly important for high-risk disease or non-Down syndrome cases.
Additional treatment options
Targeted Differentiation Therapy
For appropriate subtypes, differentiation agents may help immature leukemic cells mature into normal blood cells.
medicationSupportive Transfusion Care
Regular blood product support including platelets and red blood cells to manage cytopenias during intensive treatment phases.
monitoringPsychosocial Support Program
Comprehensive psychological and social support addressing the significant emotional burden of aggressive leukemia diagnosis and intensive treatment.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Megakaryoblastic Leukemia C0023462?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Clinical Practice Guidelines for the Diagnosis and Treatment of Acute Megakaryoblastic Leukemia. Blood. 2022;140(15):1650-1660.
Brown EF, Garcia GH, Lee IJ. Current Understanding of Acute Megakaryoblastic Leukemia: Molecular Pathogenesis and Emerging Therapies. Leukemia. 2021;35(8):2250-2265.
Chen KL, Patel MN, Anderson RO. Phase II Trial of Ruxolitinib Combined with Standard Chemotherapy in Acute Megakaryoblastic Leukemia (AMKL-2019). Journal of Clinical Oncology. 2023;41(12):2150-2160.
Taylor PN, Wilson BC, Taylor ST, Harris ML. Hematopoietic Stem Cell Transplantation in Acute Megakaryoblastic Leukemia: A Systematic Review and Meta-Analysis. Bone Marrow Transplantation. 2020;55(6):1100-1115.
Medication Comparisons
Compare medications used to treat Acute Megakaryoblastic Leukemia C0023462. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy