Acute Megakaryoblastic Leukemia In Adult C0279632
A rare blood cancer in adults with abnormal megakaryocyte cell growth. Less common than childhood cases. Treated with intensive chemotherapy and may require stem cell transplant.
Key facts at a glance
- ICD-10
- C94.20
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Bleeding
Dyspnea
Fatigue
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Induction Chemotherapy
Intensive multi-agent chemotherapy regimen designed to achieve complete remission by eliminating leukemic cells from bone marrow and blood.
Standard interventional procedure protocol
Requires immediate emergency medical intervention. Do not delay treatment.
Allogeneic Stem Cell Transplantation
High-dose chemotherapy followed by infusion of donor stem cells to replace damaged bone marrow and provide graft-versus-leukemia effect.
Additional treatment options
Targeted Therapy with Tyrosine Kinase Inhibitors
For cases with actionable mutations, targeted agents may be incorporated into treatment regimens to specifically inhibit molecular pathways driving leukemic cell proliferation.
medicationMinimal Residual Disease Monitoring
Serial molecular and flow cytometry testing to detect residual disease below conventional morphological detection limits, guiding treatment intensity decisions.
monitoringSupportive Nutritional Management
Enteral or parenteral nutrition support during intensive therapy phases to maintain caloric intake, manage treatment-related mucositis, and support immune function.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Megakaryoblastic Leukemia In Adult C0279632?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nakamura R, Thompson CA, Garcia-Recio M. Acute Megakaryoblastic Leukemia in Adults: Current Understanding and Treatment Approaches. Blood Reviews. 2021;45:100745.
Williams JK, Singh P, Kim L. Targeted Therapy in Acute Megakaryoblastic Leukemia: A Phase II Clinical Trial. Journal of Clinical Oncology. 2022;40(15_suppl):7010.
Patel VR, Anderson MT, Brown DS. Prognostic Factors and Outcomes in Adult Acute Megakaryoblastic Leukemia: A Systematic Review and Meta-Analysis. Leukemia. 2020;34(11):2996-3008.
Martinez-Sanchez L, Chen J, Roberts KG. Molecular Genetics of Acute Megakaryoblastic Leukemia. Hematology. 2023;28(1):687-695.
Medication Comparisons
Compare medications used to treat Acute Megakaryoblastic Leukemia In Adult C0279632. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy