Acute Monocytic Leukemia C0023465
An aggressive leukemia affecting monocytic blood cells that multiply rapidly. More common in older adults. Treated with chemotherapy and sometimes stem cell transplant.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Fatigue
(hematologic)Mucosal bleeding
(hematologic)Night sweats
(hematologic)Hepatosplenomegaly
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Induction Chemotherapy
Intensive combination chemotherapy typically using cytarabine and an anthracycline to achieve complete remission by eliminating leukemic cells from bone marrow and blood.
Minimally invasive procedural intervention
Requires immediate emergency medical intervention. Do not delay treatment.
Allogeneic Stem Cell Transplant
High-dose chemotherapy followed by infusion of healthy stem cells from a matched donor to replace diseased bone marrow and establish immune reconstitution.
Additional treatment options
Consolidation Chemotherapy
Additional cycles of chemotherapy after induction to eliminate residual disease and prevent relapse, often with higher-dose cytarabine regimens.
medicationSupportive Care Management
Comprehensive supportive care including transfusion support, infection prophylaxis, nutritional support, and management of treatment-related complications.
monitoringTargeted Therapy
FLT3 inhibitors or other molecularly targeted agents for patients with specific genetic mutations, used in combination with chemotherapy or as maintenance therapy.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Monocytic Leukemia C0023465?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sullivan KR, Chen WX, Rodriguez RM. Diagnosis and treatment of acute monocytic leukemia in adults: NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2022.
Martinez-Lopez J, Patel NH, Kimura F. Current therapeutic approaches in acute monocytic leukemia: a comprehensive review. Leuk Lymphoma. 2021.
Okonkwo AI, Weber G, Nakamura Y. Phase II trial of venetoclax combined with azacitidine in newly diagnosed acute monocytic leukemia. Blood Adv. 2023.
Hoffman RD, Santos PS. Acute monocytic leukemia: epidemiology, risk factors, and prognostic indicators. In: Hematologic malignancies: myeloid disorders. Springer Nature; 2020.
Medication Comparisons
Compare medications used to treat Acute Monocytic Leukemia C0023465. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy