Acute Myeloblastic Leukemia With Maturation C1879321
A type of acute myeloid leukemia where cancer cells show partial maturation. More common in adults. Often responds better to chemotherapy than AML without maturation.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Fatigue
(hematologic)Infections
(hematologic)Bone pain
(hematologic)Chloroma
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Image-guided procedure with follow-up care
Requires immediate emergency medical intervention. Do not delay treatment.
Standard Induction Chemotherapy
The '7+3' regimen combining continuous cytarabine infusion for seven days with three days of anthracycline, aiming for complete morphological remission.
Allogeneic Hematopoietic Stem Cell Transplant
Potentially curative approach using donor stem cells after myeloablative conditioning, particularly indicated for patients with high-risk cytogenetics.
Additional treatment options
Consolidation with High-Dose Cytarabine
Multiple cycles of high-dose cytarabine following induction to deepen remission and eliminate minimal residual disease in bone marrow.
medicationMinimal Residual Disease Monitoring
Serial bone marrow assessments using flow cytometry or molecular methods to detect residual leukemia cells and guide treatment decisions.
monitoringGemtuzumab Ozogamicin
Antibody-drug conjugate targeting CD33 antigen expressed on leukemic cells, used in combination with chemotherapy for CD33-positive cases.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloblastic Leukemia With Maturation C1879321?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Wei AH, Appelbaum FR, et al. Diagnosis and management of AML in adults: 2022 ELN recommendations from an international expert panel. Blood. 2022.
Kantarjian HM, Short NJ, Rausch PT, et al. Acute myeloid leukemia: current paradigm and future directions. CA Cancer J Clin. 2022.
Lancet JE, Uy GL, Newell LF, et al. Vyxeos liposomal injection for previously untreated AML with myelodysplasia-related changes. J Clin Oncol. 2021.
Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms: revised WHO and FAB classifications. Haematologica. 2019.
Medication Comparisons
Compare medications used to treat Acute Myeloblastic Leukemia With Maturation C1879321. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy