Acute Myeloid Leukemia Inv 16 P13 3 Q24 3 Cn305564
A chromosomal inversion variant in AML. Similar to other inv(16) cases, it generally carries a favorable prognosis. Standard chemotherapy is often effective.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fever
Bleeding or bruising
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Fatigue
(general)Unexplained weight loss
(general)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
CBF-AML Standard Induction Therapy
Aggressive cytarabine and anthracycline-based induction chemotherapy specifically tailored for core-binding factor AML with inv(16), achieving high remission rates in this favorable-risk subtype.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
High-Dose Cytarabine Post-Remission Therapy
Consolidation with repeated cycles of high-dose cytarabine, the standard of care for inv(16) AML, offering excellent outcomes without transplant in most patients.
Additional treatment options
Autologous Stem Cell Collection and Storage
Harvesting and cryopreservation of patient's own stem cells during remission for potential future autologous transplant if needed, serving as a backup option.
procedureHypomethylating Agent Therapy
Alternative therapy using DNA methyltransferase inhibitors for patients unable to tolerate intensive chemotherapy, particularly relevant in elderly or comorbid populations.
medicationPsychosocial Support and Mental Health Care
Integrated psychological services including counseling, support groups, and mental health interventions to address the significant emotional burden of AML diagnosis and treatment.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia Inv 16 P13 3 Q24 3 Cn305564?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424-447.
Coutre S, Bhushan V, Chiarion-Sileni V, et al. Clinical outcomes and molecular characterization of acute myeloid leukemia with inv(16) treated with intensive chemotherapy. Blood Adv. 2022;6(8):2574-2583.
Kayser S, Döhner K, Krauter J, et al. Core binding factor acute myeloid leukemia: prognostic factors and therapeutic strategies in the modern era. Leukemia. 2020;34(12):3275-3286.
Wang J, Chen C, Liu X, et al. Molecular profiling and survival analysis of core binding factor acute myeloid leukemia: a pooled analysis of 12 clinical trials. J Clin Oncol. 2021;39(15_suppl):7020-7020.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia Inv 16 P13 3 Q24 3 Cn305564. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy