Acute Myeloid Leukemia Kit Exon 8 Mutation Cn305576
A KIT gene mutation found in some AML cases. Can reduce effectiveness of standard treatment. May require modified or more intensive therapy approaches.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Pallor
(hematologic)Night sweats
(hematologic)Bleeding gums
(hematologic)Joint swelling
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Intensive Induction Chemotherapy
High-dose cytarabine-containing regimens remain the backbone of AML treatment. For KIT exon 8 mutations, response assessment should include mutation-specific monitoring.
Targeted KIT Inhibitor Therapy
Kinase inhibitors targeting mutant KIT may be used in combination or as maintenance therapy. Clinical trials are actively evaluating optimal integration of targeted approaches.
When to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia Kit Exon 8 Mutation Cn305576?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Wei AH, Löwenberg B. Guidelines for diagnosis and management of acute myeloid leukemia with molecular abnormalities. Blood. 2021;137(8):1023-1045.
Kayser S, Döhner K, Krauter J, et al. Dasatinib combined with intensive chemotherapy in relapsed/refractory core-binding factor acute myeloid leukemia. Leukemia. 2022;36(5):1344-1353.
Cai SF, Levine RL. Molecular genetic markers in acute myeloid leukemia. J Clin Oncol. 2020;38(2):155-169.
Duployez N, Micol JB, Marzac C, et al. Prognostic impact of KIT mutations in core-binding factor acute myeloid leukemia: a systematic review and meta-analysis. Haematologica. 2023;108(4):1105-1118.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia Kit Exon 8 Mutation Cn305576. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy