Acute Myeloid Leukemia Loss Of Chromosome 17p Cn305561
Loss of chromosome 17p in AML removes genetic material including the TP53 gene. This typically indicates more aggressive disease with a poorer outlook.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Easy bruising
(hematologic)Fever
(hematologic)Unexplained weight loss
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Venetoclax-Based Hypomethylating Agent Therapy
Combination therapy using venetoclax with azacitidine or decitabine for AML with 17p deletion, which is an aggressive chromosomal abnormality. This targeted approach addresses the TP53 dysfunction common in 17p deletion cases.
Allogeneic Stem Cell Transplantation
High-dose chemotherapy followed by infusion of donor stem cells to achieve durable remission in AML with 17p deletion. This is the only potentially curative option for this high-risk cytogenetic abnormality.
Additional treatment options
Intensive Induction Chemotherapy
Standard cytarabine and anthracycline-based induction chemotherapy regimen tailored for high-risk AML. Response rates are lower in 17p deletion but may serve as bridge to transplant.
medicationMinimal Residual Disease Monitoring
Regular molecular and flow cytometry assessment to detect early relapse in AML with 17p deletion. Frequent monitoring allows for timely intervention before morphological relapse.
monitoringPsychosocial Support Services
Comprehensive psychological counseling and support groups addressing the significant emotional burden of high-risk AML diagnosis. Includes stress management and coping strategies.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia Loss Of Chromosome 17p Cn305561?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey EH, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017.
Kadia TM, Ravandi F, O'Brien S, et al. Proposals for the clinical classification of chromosome 17p abnormalities in acute myeloid leukemia. Haematologica. 2021.
Wei AH, Tiong IS, Ritchie EK, et al. Venetoclax plus LDAC for newly diagnosed AML ineligible for intensive chemotherapy: a phase 3 randomized placebo-controlled trial. Lancet Haematol. 2022.
Chbani A, El Khotabi S, Alami R, et al. TP53 mutations and chromosome 17p deletions in acute myeloid leukemia: systematic review and meta-analysis of prognostic impact. Leuk Res. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy