Acute Myeloid Leukemia Monosomy 5 Cn305546
AML with monosomy 5 involves loss of chromosome 5, which is associated with poor-risk disease. It often occurs in secondary AML. Treatment may require intensive therapy or transplant.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fever
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Severe fatigue
(hematologic)Petechiae
(hematologic)Splenomegaly
(hepatic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Induction Chemotherapy
Intensive chemotherapy regimen designed to achieve complete remission by eliminating leukemic cells from bone marrow. Typically involves cytarabine combined with anthracycline agents.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Allogeneic Stem Cell Transplantation
High-dose chemotherapy followed by infusion of donor stem cells to replace damaged bone marrow and provide graft-versus-leukemia effect. This is the only potentially curative option for monosomy 5 AML.
Additional treatment options
Supportive Transfusion Therapy
Regular blood product transfusions including packed red blood cells and platelets to manage cytopenias until chemotherapy takes effect. Includes antimicrobial prophylaxis during neutropenic periods.
monitoringNeutropenic Dietary Management
Specialized nutrition support focusing on food safety and adequate caloric intake during immunosuppression. Emphasizes well-cooked foods and avoidance of raw produce to prevent infections.
dietaryPsycho-oncology Support Services
Counseling and psychological intervention to address anxiety, depression, and coping challenges associated with AML diagnosis and intensive treatment. Includes family counseling and end-of-life planning when appropriate.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia Monosomy 5 Cn305546?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel on behalf of the European LeukemiaNet. Blood. 2010;115(3):453-474.
Mrózek K, Marcucci G, Paschka P, et al. Clinical relevance of mutations and gene-expression changes in adult cytogenetically normal acute myeloid leukemia. J Clin Oncol. 2012;30(9):991-1006.
Kantarjian H, O'Brien S, Cortes J, et al. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome. Cancer. 2014;120(3):366-375.
Schneider F, Hoster E, Schneider S, et al. Age-dependent frequencies of additional chromosomal abnormalities and their prognostic impact in 1748 patients with acute myeloid leukemia. Haematologica. 2016;101(4):e140-e143.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia Monosomy 5 Cn305546. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy