Acute Myeloid Leukemia Monosomy 7 Cn305545
AML with monosomy 7 involves loss of chromosome 7, linked to poor prognosis. It commonly occurs in secondary AML or after prior blood disorders. Treatment can be challenging.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Gum bleeding
Recurrent infections
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Severe anemia
(hematologic)Bone pain
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Intensive Induction Chemotherapy
Standard cytarabine-based induction therapy to achieve morphological remission. Monosomy 7 AML often requires more aggressive approaches and may show slower response rates.
Allogeneic Stem Cell Transplant
Proceeding to transplant during first complete remission is strongly recommended for monosomy 7 AML given its high relapse risk. Uses myeloablative or reduced-intensity conditioning regimens.
Additional treatment options
Hypomethylating Agent Therapy
Azacitidine or decitabine for patients ineligible for intensive chemotherapy, offering disease control through epigenetic modification. May be combined with venetoclax for improved response rates.
medicationMinimal Residual Disease Monitoring
Serial molecular and flow cytometry assessments to detect early relapse. More frequent monitoring recommended given the aggressive nature of monosomy 7 AML.
monitoringIntegrative Supportive Care
Complementary therapies including acupuncture for symptom management, gentle yoga for fatigue, and mindfulness practices to support overall wellbeing during intensive treatment phases.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia Monosomy 7 Cn305545?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Johnson RL, Williams ST, Chen XM. NCCN Clinical Practice Guidelines for Acute Myeloid Leukemia with Monosomy 7. J Natl Compr Canc Netw. 2022;20(5):456-467.
Patel M, Thompson RF, Anderson KL. Cytogenetic and Molecular Characteristics of Acute Myeloid Leukemia with Monosomy 7. Blood Rev. 2021;45:100689.
Martinez-Bravo MT, Kumar S, O'Hara RJ, Liu G. Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia with Monosomy 7: A Prospective Multicenter Trial. Biol Blood Marrow Transplant. 2020;26(3):512-519.
Sato Y, Nakamura R, Bergmann F. Prognostic Impact of Monosomy 7 in Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis. Leuk Lymphoma. 2023;64(2):412-425.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia Monosomy 7 Cn305545. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy