Acute Myeloid Leukemia T 1 11 Q21 Q23 Cn305537
A blood cancer involving a chromosomal translocation between chromosomes 1 and 11, affecting the KMT2A gene. This rearrangement is seen in both adults and children and is generally associated with a poorer prognosis, often requiring intensive treatment.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Neurological symptoms
Fever
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Fatigue
(hematologic)Bone pain
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
AML-Directed Induction Chemotherapy
Combination chemotherapy with cytarabine and anthracycline to achieve morphological remission. Standard of care for medically fit patients with this translocation.
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Consolidation Chemotherapy
Additional cycles of high-dose cytarabine following induction to eliminate residual disease and prevent relapse. Typically 2-4 cycles depending on risk stratification.
Additional treatment options
Allogeneic Stem Cell Transplantation
Considered for high-risk patients with this translocation. Provides graft-versus-leukemia effect which may overcome adverse cytogenetic features.
procedureMaintenance Therapy
Lower intensity ongoing treatment after consolidation to maintain remission. May include hypomethylating agents or targeted therapies based on molecular findings.
medicationSerial Bone Marrow Assessment
Regular monitoring of treatment response through bone marrow biopsies and molecular testing. Essential for detecting relapse early and guiding further therapy decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 1 11 Q21 Q23 Cn305537?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453-474.
Meyer C, Burmeister T, Groger D, et al. The MLL recombinome of acute leukemias in 2017. Leukemia. 2018;32(2):273-284.
Krivtsov AV, Figueroa ME, Sinha AU, et al. Cell of origin determines clinically relevant subtypes of MLL-rearranged AML. J Clin Invest. 2013;123(2):725-733.
Schoch C, Schnittger S, Klaus M, Kern W, Hiddemann W, Haferlach T.AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases. Blood. 2003;102(7):2395-2402.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T 1 11 Q21 Q23 Cn305537. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy