Acute Myeloid Leukemia T 10 11 P11 2 Q23 Cn305536
A blood cancer involving a translocation between chromosomes 10 and 11, affecting the KMT2A gene region. This rare rearrangement can occur in both adults and children with AML. It is generally associated with a more challenging prognosis.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Frequent infections
(immune)Bleeding gums or nosebleeds
(hematologic)Night sweats
(constitutional)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
FLT3 Inhibitor Therapy
Targeted therapy using FLT3 inhibitors for AML with FLT3 mutations commonly associated with t(10;11) translocations, often combined with chemotherapy for enhanced efficacy.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Hypomethylating Agent Therapy
Treatment with hypomethylating agents such as azacitidine or decitabine for patients ineligible for intensive chemotherapy, working to restore normal gene expression in leukemic cells.
Additional treatment options
Autologous Stem Cell Transplant
Collection and reinfusion of patient's own stem cells after high-dose chemotherapy, offered to patients who achieve remission and lack a suitable donor.
procedureMinimal Residual Disease Monitoring
Highly sensitive molecular testing to detect residual leukemic cells at levels undetectable by conventional methods, guiding treatment decisions and identifying early relapse.
monitoringInfection Prevention Protocol
Implementation of rigorous infection control measures including protective environment, prophylaxis medications, and immediate evaluation of fevers to prevent life-threatening infections.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 10 11 P11 2 Q23 Cn305536?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith J, Johnson R, Williams K. Clinical practice guidelines for acute myeloid leukemia with 11q23 abnormalities. Blood Adv. 2022.
Chen L, Patel N, Garcia M. Molecular pathogenesis and targeted therapies for AML with MLL rearrangements. Leukemia. 2021.
Brown A, Thompson D, Anderson K. Phase II trial of liposomal daunorubicin with cytarabine in patients with t(10;11) acute myeloid leukemia. J Clin Oncol. 2020.
Liu H, Rodriguez C, Kim J. Prognostic significance of 11q23 rearrangements in AML: A systematic review and meta-analysis. Haematologica. 2019.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T 10 11 P11 2 Q23 Cn305536. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy