Acute Myeloid Leukemia T 11 19 Q23 P13 Cn305541
A type of acute myeloid leukemia marked by a specific chromosomal change affecting cell growth. It leads to rapid production of abnormal white blood cells. Treatment focuses on chemotherapy followed by transplant in eligible patients.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Easy bruising or petechiae
(hematologic)Recurrent infections
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
High-Dose Cytarabine Induction
High-dose cytarabine-based regimens recommended for MLL-rearranged AML to achieve deeper remission. This approach has shown improved outcomes compared to standard-dose protocols for this cytogenetic subgroup.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Consolidation with Stem Cell Transplant
Early allogeneic transplant in first remission is strongly recommended for t(11;19) AML given its aggressive biology. The procedure provides both dose-intensive chemotherapy and graft-versus-leukemia effect.
Additional treatment options
Demethylating Agent Therapy
Hypomethylating agents like azacitidine or decitabine may be used for older or transplant-ineligible patients as a less intensive alternative that still targets the epigenetic abnormalities in MLL leukemia.
medicationChimeric Antigen Receptor T-Cell Monitoring
For patients receiving CAR-T cell therapies in clinical trials, regular assessment of CAR-T cell persistence and B-cell aplasia is essential for managing efficacy and toxicity.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 11 19 Q23 P13 Cn305541?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017.
Meyer C, Burmeister T, Gröger D, et al. The MLL recombinome of acute leukemias in 2017. Leukemia. 2018.
Kayser S, Schlenk RF, Travella S, et al. Prognostic significance of FLT3 internal tandem duplication and nucleophosmin mutations in patients with acute myeloid leukemia and normal cytogenetics. J Clin Oncol. 2019.
Schoch C, Schnittger S, Klaus M, et al. AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact. Cancer. 2020.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T 11 19 Q23 P13 Cn305541. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy