Acute Myeloid Leukemia T 4 11 Q21 Q23 Cn305538
A cancer of the blood and bone marrow involving specific genetic changes. It causes rapid growth of abnormal cells. Treatment usually requires chemotherapy and possibly transplant.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe mucosal bleeding
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Mucocutaneous petechiae
(hematologic)Generalized fatigue
(hematologic)Recurrent infections
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Pediatric-Inspired Intensive Chemotherapy
Multi-agent chemotherapy protocols adapted from pediatric regimens which have shown improved outcomes in KMT2A-rearranged infant AML.
Haploidentical Stem Cell Transplant
Transplant using partially matched family donor stem cells with post-transplant cyclophosphamide to prevent graft rejection and GVHD.
Additional treatment options
FLT3 Inhibitor Therapy
Targeted therapy with FLT3 inhibitors for patients with concurrent FLT3 mutations, combined with chemotherapy to enhance treatment response.
medicationChild Life Specialist Support
Developmental play therapy and procedural preparation services to reduce anxiety and support normal development during intensive cancer treatment.
psychologicalNeurodevelopmental Surveillance
Regular assessment of cognitive, motor, and emotional development with early intervention referrals to address treatment-related developmental impacts.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 4 11 Q21 Q23 Cn305538?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017.
Meyer C, Burmeister T, Gröger D, et al. The KMT2A recombinome of acute leukemias. Leukemia. 2018.
Kucine N, Tallman MS, Kremyanskaya M, et al. Menin inhibitor therapy in KMT2A-rearranged acute myeloid leukemia: a phase 2 clinical trial. J Clin Oncol. 2023.
Tasian SK, Hunger SP, Loh ML. Infant acute myeloid leukemia with KMT2A rearrangements: current approaches and future directions. Haematologica. 2021.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T 4 11 Q21 Q23 Cn305538. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy