Acute Myeloid Leukemia T 9 22 Q34 1 Q11 2 Cn305555
AML with the Philadelphia chromosome, involving chromosomes 9 and 22. This form has a poor outlook but may respond to targeted therapy.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Shortness of breath
(hematologic)Frequent infections
(hematologic)Swollen lymph nodes
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Tyrosine Kinase Inhibitor-Based Therapy
BCR-ABL1 targeted therapy with TKIs such as dasatinib or ponatinib combined with chemotherapy. This Philadelphia chromosome-positive AML requires specific targeted approaches alongside conventional treatment.
Allogeneic Stem Cell Transplant
Considered the only potentially curative option for Ph+ AML. Transplantation after achieving remission with TKI-based therapy provides the best long-term disease control.
Additional treatment options
Hyperfractionated Cyclophosphamide
Intensive conditioning regimen incorporating hyper-CVAD with TKI for transplant eligible patients. May provide deeper responses before transplantation.
medicationPhysical Function Preservation Program
Structured exercise program adapted for leukemia patients to maintain muscle mass, reduce fatigue, and improve treatment tolerance. Includes aerobic conditioning and resistance training appropriate to treatment phase.
lifestyleChronic Illness Adjustment Counseling
Specialized psychological intervention addressing the unique challenges of Ph+ leukemia including treatment uncertainty, family planning decisions, and long-term medication adherence concerns.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia T 9 22 Q34 1 Q11 2 Cn305555?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Arber DA, Borowitz MJ, Cessna M, et al. Initial Diagnostic Workup of Acute Leukemia: Guideline from the College of American Pathologists and the American Society of Hematology. Arch Pathol Lab Med. 2017.
Döhner H, Wei AH, Appelbaum FR, et al. Diagnosis and management of AML in adults: 2022 ELN recommendations from an international expert panel. Blood. 2022.
Stone RM, Mandrekar SJ, Sanford BL, et al. Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation. N Engl J Med. 2017.
Khwaja A, Bjorkholm M, Gale RE, et al. Acute myeloid leukaemia. Nat Rev Dis Primers. 2016.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia T 9 22 Q34 1 Q11 2 Cn305555. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy