Acute Myeloid Leukemia With Fus Erg Fusion C5856227
A rare acute myeloid leukemia involving a fusion between the FUS and ERG genes, disrupting normal blood cell development. It can occur in adults and is generally considered high-risk. Treatment usually requires intensive chemotherapy and possibly stem cell transplant.
Key facts at a glance
- ICD-10
- C92.61, C92.A1, C92.A2
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Sudden weakness
Fatigue
(hematologic)Fever
(hematologic)Unexplained weight loss
(general)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Induction Chemotherapy
High-dose chemotherapy protocol combining cytarabine with anthracycline agents to induce morphological remission. Given the aggressive nature of ERG-fusion AML, more intensive regimens may be considered.
Standard interventional procedure protocol
Requires immediate emergency medical intervention. Do not delay treatment.
Allogeneic Stem Cell Transplant
Proceeding to transplantation early in first complete remission is often recommended for this high-risk subtype. The procedure involves intensive conditioning followed by infusion of donor stem cells.
Additional treatment options
Hypomethylating Agent Combination
Therapeutic approach using hypomethylating agents either alone or in combination with other drugs. These agents modify gene expression patterns and may be used when standard chemotherapy is not feasible.
medicationSupportive Care and Infection Prevention
Comprehensive supportive management including prophylactic antibiotics, antifungals, and antivirals during neutropenic periods. Blood product support and growth factor administration reduce complication risks.
medicationFrequent Response Assessment
Regular bone marrow evaluation and molecular testing to assess treatment response and detect early relapse. Given the high-risk nature of this subtype, more frequent monitoring is typically employed.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With Fus Erg Fusion C5856227?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel. Blood. 2017.
Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol. 2011.
Schlenk RF, Dohner K, Krauter J, et al. Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients. N Engl J Med. 2009.
Petrovic J, Perez MA, Torres A, et al. Prognostic impact of chromosomal abnormalities in acute myeloid leukemia: a systematic review and meta-analysis. Leukemia. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy