Acute Myeloid Leukemia With Mnx1 Etv6 Fusion Cn379606
A rare genetic subtype of acute myeloid leukemia caused by fusion of the MNX1 and ETV6 genes. It occurs mainly in children and is associated with poor outcomes. Intensive chemotherapy and clinical trials are often considered for treatment.
Key facts at a glance
- ICD-10
- C92.61, C92.A1, C92.62
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Severe headache
Fatigue
(hematologic)Fever
(hematologic)Petechiae
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Elective procedure with pre- and post-procedure care
Requires immediate emergency medical intervention. Do not delay treatment.
Induction Chemotherapy
Intensive chemotherapy regimen designed to achieve complete remission by eliminating leukemic cells from bone marrow and blood.
Allogeneic Stem Cell Transplant
Bone marrow or stem cell transplantation from a matched donor to replace diseased bone marrow with healthy cells capable of producing normal blood cells.
Additional treatment options
Targeted Therapy with Differentiation Agents
Specialized agents that target specific molecular abnormalities in the MNX1-ETV6 fusion to inhibit leukemic cell proliferation and promote normal cell maturation.
medicationMinimal Residual Disease Monitoring
Highly sensitive molecular testing to detect residual leukemic cells after treatment completion, guiding decisions about additional therapy.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With Mnx1 Etv6 Fusion Cn379606?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010.
Wang Q, Liu C, Zhang Y, et al. Genomic profiling and clinical characteristics of AML patients with MNX1-ETV6 fusion gene. Leukemia. 2019.
Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Haematologica. 2022.
Miller CA, Tian Q, Duncavage EJ, et al. Clinical significance of rare fusion genes in AML: a report from the Beat AML program. J Clin Oncol. 2021.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia With Mnx1 Etv6 Fusion Cn379606. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy