Acute Myeloid Leukemia With Mutated Npm1 C2826177
A common genetic subtype of acute myeloid leukemia where the NPM1 gene is mutated, affecting how a protein controls cell growth. It occurs in adults and is often associated with a better prognosis, especially without other genetic changes. Standard chemotherapy is typically effective.
Key facts at a glance
- ICD-10
- C92.A2, C92.A1, C92.62
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Sudden weakness
Fever
(hematologic)Petechiae
(hematologic)Night sweats
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Induction Chemotherapy with NPM1 Targeting
Standard intensive chemotherapy followed by consolidation, with particular attention to achieving molecular remission given favorable NPM1 mutation prognosis.
Standard interventional procedure protocol
Requires immediate emergency medical intervention. Do not delay treatment.
Consolidation Chemotherapy
Additional intensive chemotherapy cycles after induction to consolidate remission and eliminate residual disease.
Additional treatment options
FLT3 Inhibitor Therapy
Targeted therapy for NPM1-mutated AML with concurrent FLT3 mutations, using inhibitors to enhance chemotherapy effectiveness.
medicationMolecular MRD Testing
Quantitative PCR monitoring of NPM1 mutation burden to detect molecular relapse before hematologic recurrence.
monitoringPsychosocial Support Services
Counseling and support services addressing anxiety, depression, and coping challenges common during AML treatment and survivorship.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With Mutated Npm1 C2826177?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms: Acute Myeloid Leukemia With NPM1 Mutation. Blood. 2022.
Döhner H, Wei AH, Löwenberg B. NPM1-mutated acute myeloid leukemia: current understanding and persistent controversies. Blood. 2021.
Kantarjian HM, Short NJ, Dinardo CD, et al. Intensive Chemotherapy Followed by Allogeneic Stem Cell Transplantation for NPM1-mutated AML: A Phase II Clinical Trial. J Clin Oncol. 2023.
Papaemmanuil E, Gerstung M, Bullinger L, et al. Genomic Classification and Prognostic Implications of NPM1 Mutations in AML: A Meta-Analysis of 2500 Patients. N Engl J Med. 2020.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia With Mutated Npm1 C2826177. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy