Acute Myeloid Leukemia With Npm1 Somatic Mutations C4706386
A blood cancer affecting bone marrow cells with a mutation in the NPM1 gene. Common in adults. Treatment often includes chemotherapy, with prognosis varying by additional genetic factors.
Key facts at a glance
- ICD-10
- C92.61, C92.62, C92.A1
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Vision loss
Fatigue
(hematologic)Frequent infections
(hematologic)Gingival swelling
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Induction Chemotherapy
High-dose cytarabine-based combination chemotherapy to achieve morphologic complete remission in NPM1-mutated disease.
Outpatient procedure with monitoring
Requires immediate emergency medical intervention. Do not delay treatment.
Consolidation with High-Dose Cytarabine
Intensified cytarabine therapy following induction to deepen remission and prevent relapse in NPM1-mutated leukemia.
Additional treatment options
Stem Cell Transplant in High-Risk Cases
Transplant indicated for patients with concurrent FLT3 mutations or those failing to achieve molecular remission.
procedureSerial Molecular Monitoring
Regular quantitative assessment of NPM1 mutation levels in peripheral blood or bone marrow to guide therapeutic decisions.
monitoringInfection Prevention Measures
Strict hygiene protocols, vaccination optimization, and avoidance of crowded indoor spaces during periods of neutropenia.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With Npm1 Somatic Mutations C4706386?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010.
Döhner H, Gaidzick L, Larson RA. NPM1-mutated acute myeloid leukemia: current understanding and future directions. Leukemia. 2022.
Wei AH, Montesinos P, Ivanov V, et al. Venetoclax plus LDAC for newly diagnosed AML ineligible for intensive chemotherapy: a phase 3 randomized placebo-controlled trial. Blood. 2020.
Patel JP, Levine RL, Gönen M, et al. Prognostic relevance of genetic alterations in adult AML: a systematic review and meta-analysis. J Clin Oncol. 2022.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia With Npm1 Somatic Mutations C4706386. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy