Acute Myeloid Leukemia With Recurrent Genetic Anomaly C1275661
A category of blood cancer with specific genetic changes that occur repeatedly. Genetic testing is essential to guide treatment, which may include chemotherapy and targeted therapies.
Key facts at a glance
- ICD-10
- C92.62, C92.A2, C92.61
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Sudden weakness
Fatigue
(hematologic)Easy bruising or bleeding
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Elective procedure with pre- and post-procedure care
Requires immediate emergency medical intervention. Do not delay treatment.
FLT3 Inhibitor Therapy
Targeted molecular therapy using FLT3 inhibitors for patients with FLT3 mutations, a common genetic abnormality in AML. These agents disrupt leukemic cell proliferation and survival signaling pathways.
Consolidation Chemotherapy
Post-remission intensive chemotherapy cycles to eliminate remaining leukemic cells and prevent relapse. Treatment intensity depends on cytogenetic risk stratification and patient fitness.
Additional treatment options
Autologous Stem Cell Rescue
Collection and reinfusion of patient's own stem cells following high-dose chemotherapy conditioning regimen. Less immunosuppressive than allogeneic transplant with no graft-versus-host disease risk.
procedureMolecular Genetic Surveillance
Ongoing monitoring of specific genetic mutations to guide treatment decisions and detect molecular relapse before clinical symptoms. Includes next-generation sequencing and digital PCR techniques.
monitoringInfection Prevention Protocol
Comprehensive infection control measures including prophylactic antibiotics, neutropenic precautions, and vaccination strategy. Reduces morbidity from infectious complications during immunosuppression.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With Recurrent Genetic Anomaly C1275661?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel. Blood. 2010.
Khwaja A, Bjorkholm M, Gale RE, Levine RL, Jordan CT, Ehninger G, et al. Acute myeloid leukaemia. Nat Rev Dis Primers. 2016.
Stone RM, Mandrekar SJ, Sanford BL, Laumann K, Geyer S, Bloomfield CD, et al. Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation. N Engl J Med. 2017.
Wang ES, Frankfurt O, Uy GL, Ma JC, Platanias LC, Ritchie EK, et al. FLT3 inhibitors in the management of acute myeloid leukemia with FLT3 mutation: a systematic review and meta-analysis. Leukemia. 2022.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia With Recurrent Genetic Anomaly C1275661. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy