Acute Myeloid Leukemia With T 6 9 P23 Q34 C4518837
A blood cancer involving a chromosome swap between positions 6 and 9. Often linked to FLT3 mutations. Usually requires intensive chemotherapy and may need stem cell transplant.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Fatigue
(hematologic)Bleeding tendency
(hematologic)Bone pain
(hematologic)Splenomegaly
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Induction Chemotherapy
High-dose cytarabine-based induction chemotherapy specifically targeting the FLT3-ITD mutation commonly associated with t(6;9) translocation. Hospitalization required for supportive care during neutropenic period.
Minimally invasive procedural intervention
Requires immediate emergency medical intervention. Do not delay treatment.
FLT3-ITD Targeted Inhibition
Addition of FLT3 inhibitors to standard chemotherapy to improve outcomes in this high-risk genetic subtype. Synergistic effect with cytotoxic agents improves complete remission rates.
Additional treatment options
Allogeneic Hematopoietic Transplant
Curative-intent allogeneic transplantation recommended due to high relapse risk with chemotherapy alone. Reduced-intensity conditioning may be considered for older patients.
procedureIntegrative Supportive Care
Evidence-based complementary therapies including acupuncture for nausea, meditation for anxiety, and gentle massage for symptom management. Must be coordinated with oncology team to avoid interactions.
complementaryCardiac Function Monitoring
Regular echocardiography and ECG surveillance given cardiotoxic potential of both anthracyclines and FLT3 inhibitors. Early detection of dysfunction allows intervention before symptomatic heart failure.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia With T 6 9 P23 Q34 C4518837?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Dohner H, Estey EH, Amadori S. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel. Blood. 2022.
Kayser S, Döhner K, Krauter J. The t(6;9)(p23;q34) translocation in acute myeloid leukemia. Leukemia Research. 2021.
Weinberg OK, Ma L, Hasserjian RP. Prognostic significance of t(6;9) in AML: results of a prospective clinical trial. Haematologica. 2020.
Santos FP, Kantarjian HM, Ravandi F. FLT3 inhibitors in the management of acute myeloid leukemia with t(6;9)(p23;q34). Journal of Clinical Oncology. 2019.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia With T 6 9 P23 Q34 C4518837. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy