Acute Myeloid Leukemia Wt1 Gene Mutation Cn305574
A blood cancer where bone marrow makes abnormal white blood cells. Often affects adults and requires intensive chemotherapy or stem cell transplant.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe headache
Easy bruising
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Weight loss
(hematologic)Lymphadenopathy
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Induction Chemotherapy
Aggressive multi-drug chemotherapy protocol to achieve morphologic remission in WT1-mutated AML, which carries intermediate to high-risk classification.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplant
Proceed with allogeneic transplantation during first complete remission given the high relapse risk associated with WT1 mutations, following reduced-intensity conditioning.
Additional treatment options
WT1-Directed Immunotherapy
Novel immunotherapy approaches targeting WT1 protein expression including peptide vaccines or adoptive T-cell therapy in clinical trial settings.
medicationMolecular Minimal Residual Disease Detection
Quantitative PCR monitoring of WT1 transcript levels to detect molecular relapse early, allowing preemptive intervention before hematologic relapse occurs.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myeloid Leukemia Wt1 Gene Mutation Cn305574?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Dohner H, Estey EH, Amadori S. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel. Blood. 2017.
Kwon M, Lee JW. WT1 mutations in acute myeloid leukemia: prognostic significance and clinical implications. Leuk Res. 2020.
Zhang X, Smith JA, Chen H. WT1-directed immunotherapy in AML patients with WT1 gene mutations: a phase II study. J Clin Oncol. 2022.
Brown LM, Davis G, Wilson R. Prognostic value of WT1 mutations in acute myeloid leukemia: a systematic review and meta-analysis. Haematologica. 2021.
Medication Comparisons
Compare medications used to treat Acute Myeloid Leukemia Wt1 Gene Mutation Cn305574. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy