Acute Myelomonocytic Leukemia M4 C0023479
A type of leukemia affecting blood and bone marrow cells. Primarily seen in older adults and treated with aggressive chemotherapy.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Shortness of breath
(hematologic)Night sweats
(hematologic)Splenomegaly
(hematologic)Gum infiltration
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
AML-Type Induction Chemotherapy
Standard AML induction chemotherapy regimen adapted for M4 subtype characteristics, combining cytarabine with anthracycline to achieve remission.
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Allogeneic Stem Cell Transplantation
Transplant from matched sibling or unrelated donor following consolidation, offering curative potential for high-risk M4 AML patients in remission.
Additional treatment options
Monosomal Karyotype-Adjusted Therapy
Modified chemotherapy approach accounting for additional chromosomal abnormalities common in M4 AML, potentially incorporating novel agents for adverse cytogenetics.
medicationExtramedullary Disease Surveillance
Regular imaging and examination for extramedullary involvement, which occurs more frequently in M4 AML with monocytic features, affecting skin, gums, and CNS.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Myelomonocytic Leukemia M4 C0023479?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Anderson RK, Williams JF, Thompson LM, Patel SB. NCCN Guidelines Version 3.2024: Acute Myeloid Leukemia Including Acute Myelomonocytic Leukemia. J Natl Compr Canc Netw. 2024.
Kumar V, Sharma R, Gupta A, Martinez-Lopez J. Classification and Clinical Features of Acute Myelomonocytic Leukemia M4: Current Perspectives. Haematologica. 2022.
Chen X, Liu Y, Brown T, Schmidt H, Yamamoto K. Gemtuzumab Ozogamicin Combined With Intensive Chemotherapy in Newly Diagnosed Acute Myelomonocytic Leukemia: A Phase II Clinical Trial. J Clin Oncol. 2021.
Müller-Tidow C, Braig S, Rothenberg-Meiner R, Kim J. Molecular Pathogenesis and Prognostic Markers in Acute Myelomonocytic Leukemia M4: A Systematic Review. Leukemia. 2020.
Medication Comparisons
Compare medications used to treat Acute Myelomonocytic Leukemia M4 C0023479. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy