Acute Papillary Necrosis C0403468
Death of kidney tissue that can occur with diabetes or infections. Treatment focuses on managing the underlying cause.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Acute kidney injury
Flank pain
Gross hematuria
Fever
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antibiotic Therapy
Broad-spectrum antibiotics targeting urinary tract pathogens, adjusted based on culture results, to treat underlying infection driving papillary necrosis.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Urinary Tract Decompression
Relief of obstruction through ureteral stenting or percutaneous nephrostomy to prevent further renal damage and allow healing of necrotic tissue.
Additional treatment options
Glycemic Control Optimization
Intensive diabetes management with appropriate agents to control hyperglycemia, a major risk factor for papillary necrosis progression.
medicationAnalgesic Avoidance
Elimination of nephrotoxic analgesics including NSAIDs and excessive acetaminophen, which contribute to papillary necrosis development.
lifestyleRenal Function Surveillance
Regular monitoring of serum creatinine, eGFR, and imaging studies to assess disease progression and preserve remaining renal function.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Papillary Necrosis C0403468?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
European Association of Urology. EAU Guidelines on Acute Tubular Necrosis and Papillary Necrosis. Eur Urol. 2022.
Patel N, Sharma R, Williams J. Acute Papillary Necrosis: Pathophysiology and Clinical Management. Am J Nephrol. 2021.
Kumar S, Chen L, Anderson M, Garcia H. Efficacy of Early Intervention in Acute Papillary Necrosis: A Prospective Cohort Study. Clin Nephrol. 2020.
Singh R, Okonkwo C. Renal Papillary Necrosis: Etiology, Diagnosis and Treatment Approaches. Kidney Int. 2019.
Medication Comparisons
Compare medications used to treat Acute Papillary Necrosis C0403468. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy