Acute Recurrent Myoglobinuria Cn239190
Repeated episodes of muscle breakdown causing dark urine. Can result from metabolic disorders or intense exercise.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Muscle pain
(musculoskeletal)Dark urine
(renal)Muscle weakness
(musculoskeletal)Muscle stiffness
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Aggressive IV Hydration
High-volume intravenous fluid administration during acute episodes to maintain urine output and prevent myoglobin-induced acute kidney injury.
Rhabdomyolysis Management
Urgent treatment with IV fluids, electrolyte management, and consideration of mannitol or bicarbonate for severe myoglobinuria with renal impairment.
Additional treatment options
Metabolic Trigger Avoidance
Avoidance of identified metabolic triggers such as extreme exertion, fasting, cold exposure, or specific foods that precipitate myoglobinuria episodes.
dietaryModified Carbohydrate Diet
High-carbohydrate, moderate-protein dietary approach for metabolic myopathies to optimize glucose utilization and reduce muscle breakdown.
dietaryCK and Renal Function Monitoring
Regular monitoring of serum creatine kinase levels and renal function to detect subclinical episodes and prevent chronic kidney disease.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Recurrent Myoglobinuria Cn239190?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Vissing CR, Nadaj-Pakleza A, Vincitorio CM, et al. European Association of Neuromuscular Diseases: Guidelines for the management of metabolic myopathies. Neuromuscular Disorders. 2022.
Morales-Gómez C, Hernández-García A, García-Erce JA. Metabolic myopathies causing recurrent myoglobinuria: a comprehensive review. J Inherit Metab Dis. 2021.
Björkholm C, Oláhová M, Wedell A, et al. Metabolic characterization and long-term outcomes in patients with recurrent exercise-induced myoglobinuria: a prospective cohort study. Muscle Nerve. 2020.
Scalco RS, Gardiner AR, Houlden H, et al. Rhabdomyolysis and acute kidney injury in metabolic myopathies: clinical features and prognostic implications. Pediatrics. 2019.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy