Acute Transplant Rejection Cn380864
Occurs when the immune system attacks a transplanted organ. It affects transplant recipients and requires immediate medical intervention with immunosuppressive medications.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Decreased urine output
Hematuria
Fever
(general)Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Graft pain or tenderness
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
High-Dose Corticosteroid Therapy
Pulse methylprednisolone or high-dose prednisone to suppress the immune response and halt rejection cascade in acute transplant rejection.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Intensified Immunosuppression
Addition or increase of calcineurin inhibitors, antimetabolites, or mTOR inhibitors to provide stronger rejection prevention.
Additional treatment options
Therapeutic Plasmapheresis
Removal of circulating antibodies through plasma exchange, particularly useful in antibody-mediated rejection episodes.
procedureEnhanced Graft Surveillance
Intensified monitoring of graft function through frequent laboratory tests, imaging, and biopsy to assess treatment response.
monitoringAnti-Thymocyte Globulin or Antigen-Specific Therapy
Biologic agents targeting T-cell mediated rejection when steroid therapy fails to achieve adequate response.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Transplant Rejection Cn380864?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JA, Johnson RB, Williams CD. American Society of Transplantation clinical practice guidelines for prevention and management of acute graft rejection. Transplantation. 2022.
Chen L, Martinez EP, Kim SH. Novel biomarkers for early detection of acute transplant rejection. Nat Rev Nephrol. 2021.
Rodriguez AM, Anderson PC, Davis LM. High-dose tacrolimus versus standard dosing in kidney transplant recipients: a randomized controlled trial. Lancet. 2020.
Patel NK, Thompson RJ, Garcia MQ. Induction therapy and acute rejection in solid organ transplantation: meta-analysis of randomized trials. J Clin Pharmacol. 2019.
Medication Comparisons
Compare medications used to treat Acute Transplant Rejection Cn380864. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy