Acute Tubulointerstitial Nephritis C1843274
Kidney inflammation affecting the tubules and surrounding tissue, often from medications or infections. Treatment involves removing the cause and supporting kidney function.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Varies
Flank pain
(renal)Fever
(renal)Rash
(renal)Eosinophilia
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Discontinue offending agents
Immediate cessation of any medications suspected of triggering acute tubulointerstitial nephritis, which may be the only intervention needed if identified early before irreversible damage occurs.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Corticosteroid therapy
Systemic corticosteroids to suppress immune-mediated inflammation in the renal tubules and interstitium when supportive care alone is insufficient or when symptoms are severe.
Additional treatment options
Renal function surveillance
Close monitoring of serum creatinine, BUN, and electrolytes along with urinalysis to assess kidney function recovery and detect progression requiring escalation of therapy.
monitoringFluid and electrolyte management
Careful attention to hydration status and electrolyte replacement as needed, particularly when polyuria is present or tubular function is impaired.
lifestyleRenal biopsy
Percutaneous kidney biopsy to confirm diagnosis, assess degree of inflammation and fibrosis, and guide treatment decisions when clinical presentation is atypical or response to therapy is inadequate.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Acute Tubulointerstitial Nephritis C1843274?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kidney Disease Improving Global Outcomes (KDIGO). Clinical practice guideline for glomerulonephritis. Kidney Int Suppl. 2021;11(1):1-274.
Perazella MA, Markowitz GS. Drug-induced acute interstitial nephritis. Nat Rev Nephrol. 2010;6(8):461-470.
Molinario R, Espino M, Balzan A, et al. Corticosteroid therapy for acute interstitial nephritis: a systematic review and meta-analysis. Clin Kidney J. 2022;15(5):942-951.
Raghavan R, Eknoyan G. Acute interstitial nephritis: a review. Adv Chronic Kidney Dis. 2021;28(4):345-359.
Medication Comparisons
Compare medications used to treat Acute Tubulointerstitial Nephritis C1843274. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy