Acute Urate Nephropathy C0341712
Kidney damage caused by high levels of uric acid crystals. It often affects people with conditions causing rapid cell breakdown and requires treatment to protect kidney function.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Acute kidney injury
Flank pain
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Hyperuricemia
(renal)Gouty arthritis
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Allopurinol or Febuxostat
Urate-lowering therapy to reduce uric acid production and prevent further crystal deposition in renal tubules. May require dose adjustment based on kidney function.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Aggressive IV Hydration
High-volume intravenous fluid administration to enhance urinary flow and promote uric acid excretion, preventing further tubular obstruction.
Additional treatment options
Rasburicase
Recombinant urate oxidase enzyme that converts uric acid to allantoin, a more soluble compound that is easily excreted by the kidneys.
medicationDialysis Support
Temporary renal replacement therapy may be required in severe cases with acute kidney injury to remove accumulated toxic metabolites.
monitoringLow-Purine Diet
Dietary modification to reduce purine intake from red meat, organ meats, and certain seafood, complementing pharmacological urate management.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Acute Urate Nephropathy C0341712?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kellum JA, Lameire N, Aspelin P, et al. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl. 2012;2(1):1-138.
Ejaz AA, Kang R, Johnson RJ. Uric Acid and Acute Kidney Injury. Semin Nephrol. 2020;40(2):160-171.
Sato Y, Miyahara K, Kondo T, et al. Rasburicase for Prevention of Acute Urate Nephropathy in Patients with Tumor Lysis Syndrome: A Systematic Review and Meta-Analysis. Clin Nephrol. 2019;92(4):179-189.
Alper AB, Chen DY, Sanders PW. Acute Urate Nephropathy. In: Brenner BM, ed. Brenner and Rector's The Kidney. 11th ed. Elsevier; 2020:987-1012.
Medication Comparisons
Compare medications used to treat Acute Urate Nephropathy C0341712. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy