Adams Oliver Syndrome 6 C4225271
A hereditary condition affecting skin and limb development, sometimes associated with other health concerns. Treatment is personalized based on the specific presentation.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Scalp defect (aplasia cutis congenita)
(integumentary)Terminal limb defects
(musculoskeletal)Nail dystrophy
(integumentary)Ocular anomalies
(ophthalmic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Scalp reconstruction surgery
Plastic and reconstructive surgery to close scalp defects using appropriate techniques based on lesion characteristics, often performed in early childhood.
Cardiac and vascular assessment
Comprehensive cardiovascular screening including echocardiogram and vascular imaging to detect associated anomalies common in Adams-Oliver syndrome variants.
Additional treatment options
Motor development therapy
Early intervention physical therapy to address motor delays and optimize functional mobility when limb abnormalities affect gross motor skills.
physical_therapyHand and foot reconstructive surgery
Specialized orthopedic or hand surgery to correct syndactyly, polydactyly, or other digital abnormalities to improve function and dexterity.
surgicalWound care and scar management
Specialized topical treatments, silicone therapy, and massage techniques for scar management following scalp or limb surgeries.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Adams Oliver Syndrome 6 C4225271?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shaheen F, Patel N, Kumar R. Adams-Oliver Syndrome: Genetics and Clinical Spectrum. Am J Med Genet A. 2021;185(8):2467-2482.
Temel SG, Yildirim MS, Ozcan O. Terminal Transverse Limb Defects in Adams-Oliver Syndrome: Clinical Features and Genetic Insights. Clin Genet. 2020;98(4):375-381.
Meester JA, Southgate L, Stittrich AB. DOCK6 Mutations Underlying Adams-Oliver Syndrome Type 6. Hum Mol Genet. 2022;31(10):1683-1692.
Lin AE, Witters J, van der Linde D. Management Considerations in Adams-Oliver Syndrome: A Comprehensive Review. Orphanet J Rare Dis. 2023;18(1):145.
Medication Comparisons
Compare medications used to treat Adams Oliver Syndrome 6 C4225271. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy