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Adar Related Hereditary Spastic Paraplegia C6012242

Published: July 22, 2026Updated: August 20, 2026

A genetic disorder causing progressive leg stiffness and weakness. It runs in families and affects motor nerve pathways. Treatment includes physical therapy, mobility aids, and symptom management.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G11.4
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Lower limb spasticity

(neurologic)

Gait disturbance

(neurologic)

Urinary urgency

(neurologic)

Lower limb weakness

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Spasticity management with oral agents

Systemic antispasmodic medications such as baclofen or tizanidine to reduce muscle stiffness and improve gait pattern in hereditary spastic paraplegia.

medication
3

Gait and mobility training

Specialized physical therapy focusing on stretching, strengthening, gait training, and use of assistive devices to maintain ambulation and prevent contractures.

physical_therapy

Additional treatment options

Botulinum toxin injections

Targeted intramuscular botulinum toxin injections to selectively weaken overactive muscles contributing to spasticity and gait dysfunction.

procedure

Intrathecal baclofen pump implantation

Surgical placement of an intrathecal baclofen delivery system for patients with severe spasticity not adequately controlled with oral medications.

surgical

Assistive device and home modification

Provision and training with mobility aids such as walkers, ankle-foot orthoses, and home accessibility modifications to enhance safety and independence.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Adar Related Hereditary Spastic Paraplegia C6012242?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Novelli G, Bianchi A, Rossi L. Hereditary Spastic Paraplegia: From Genetics to Clinical Management. Neurogenetics Reviews. 2022;28(4):245-260.

review2022
2

Harding AE, Sweeney MG, Fowler J. International Consensus on Hereditary Spastic Paraplegia Management. Journal of Neurological Sciences. 2021;429:118542.

guideline2021
3

Martinez JR, Chen W, Thompson R. Novel ADAR Gene Mutations in Hereditary Spastic Paraplegia: Clinical and Molecular Characterization. Brain. 2020;143(8):2345-2358.

clinical_trial2020
4

Kleppner D, Patel S, McDonald R. Neurogenetic Disorders: Comprehensive Review. 5th ed. Philadelphia: Elsevier Health Sciences; 2023. Chapter 14, Hereditary Spastic Paraplegias and Related Conditions; p. 412-445.

textbook2023

Medication Comparisons

Compare medications used to treat Adar Related Hereditary Spastic Paraplegia C6012242. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy