Addictive Nitrous Oxide Use C5781427
Recreational misuse of nitrous oxide gas, sometimes called "laughing gas." Often affects young adults at social events. Treatment involves counseling, support groups, and addressing any underlying mental health concerns.
Key facts at a glance
- ICD-10
- F99
- ICD-11
- 6A00.0
- Body system
- psychiatric
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
B12 deficiency myelopathy
Mood changes or anxiety
(psychiatric)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Peripheral neuropathy
(neurological)Cognitive dysfunction
(neurological)Coordination problems
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cognitive Behavioral Therapy for Inhalant Use
CBT addresses the specific psychological mechanisms underlying nitrous oxide misuse, helping patients develop healthier coping alternatives and manage triggers associated with use.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Neurological and Nutritional Assessment
Regular monitoring of B12 levels, nerve function, and neurological status helps detect and address damage from chronic nitrous oxide exposure while guiding supplementation needs.
Additional treatment options
B12 and Folate Supplementation Support
Dietary guidance and nutritional support addressing deficiencies caused by nitrous oxide interference with B12 metabolism, supporting neurological recovery through proper nutrition.
dietaryEnvironmental Modification and Trigger Avoidance
Identifying and modifying environmental factors that facilitate nitrous oxide access, including social settings and availability, reduces opportunities for use.
lifestyleAcupuncture for Craving Reduction
Auricular acupuncture may help reduce cravings and manage withdrawal discomfort associated with nitrous oxide cessation as part of a comprehensive treatment approach.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Addictive Nitrous Oxide Use C5781427?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
van Amsterdam J, Nabben T. Clinical practice guideline for nitrous oxide abuse prevention and treatment. Addict Med. 2022.
Garcia-Rodriguez O, Freedman M. Neurological complications of recreational nitrous oxide use: a systematic review. Neurotoxicology. 2021.
Mason R, Chen L. Treatment outcomes for nitrous oxide dependency: a meta-analysis of intervention studies. J Addict Psychiatry. 2023.
Patel S, Kimura H. Nitrous oxide-induced vitamin B12 deficiency and myeloneuropathy: clinical features and diagnostic challenges. Neurology. 2020.
Medication Comparisons
Compare medications used to treat Addictive Nitrous Oxide Use C5781427. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy