Adenocarcinoma Of Skene Gland Origin C1527427
A rare cancer of the paraurethral (Skene) glands, occurring almost exclusively in adult females. Treatment typically involves surgery, sometimes followed by radiation or chemotherapy.
Key facts at a glance
- ICD-10
- N39.0
- ICD-11
- GA00.0
- Body system
- genitourinary
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(genitourinary)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pelvic pain
(genitourinary)Urinary frequency
(genitourinary)Dysuria
(genitourinary)Hematuria
(genitourinary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Radical Surgical Excision with Clear Margins
Complete surgical resection remains the primary curative approach, typically involving wide local excision or possibly exenteration depending on local invasion. Pathologic assessment of margins guides need for additional therapy.
Sentinel Lymph Node Biopsy
Identification and pathological examination of sentinel nodes determines lymph node involvement, which is critical for staging and adjuvant treatment planning. Positive nodes indicate need for more aggressive adjuvant therapy.
Additional treatment options
Adjuvant Platinum-Based Chemotherapy
Following surgical resection, platinum-based chemotherapy may be recommended for high-risk features including positive margins, lymph node involvement, or high-grade tumors. Treatment aims to eliminate micrometastatic disease.
medicationLong-Term Surveillance Imaging Protocol
Regular imaging surveillance with CT, MRI, or ultrasound detects locoregional recurrence or distant metastases in asymptomatic patients when salvage treatment is more feasible. Monitoring typically continues for 5+ years.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Adenocarcinoma Of Skene Gland Origin C1527427?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy