Adrenal Cortical Hypofunction C0405580
Reduced function of the adrenal gland's outer layer, causing fatigue, weakness, and sometimes nausea. Lifelong medication to replace missing hormones is the main treatment.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(endocrine)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypotension
(cardiovascular)Hyperpigmentation of skin
(integumentary)Salt craving
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Glucocorticoid Replacement Therapy
Lifelong corticosteroid replacement is the cornerstone of treatment for adrenal cortical hypofunction. Hydrocortisone, prednisone, or dexamethasone may be prescribed based on individual patient factors to replace deficient cortisol production.
Mineralocorticoid Replacement
For patients with primary adrenal insufficiency who lack aldosterone production, fludrocortisone is added to the regimen. This helps maintain electrolyte balance and blood pressure regulation.
Additional treatment options
Emergency Preparedness and Medical Alert
Patients should carry emergency injectable hydrocortisone and wear medical alert identification at all times. Family members should be trained in emergency adrenal crisis administration.
lifestyleIncreased Salt Intake
Dietary sodium intake may need to be increased, especially in primary adrenal insufficiency. A balanced diet rich in whole grains, lean proteins, and fruits supports overall energy levels.
dietaryRegular Endocrine Follow-up
Scheduled laboratory testing and clinical assessments monitor hormone levels, electrolyte balance, and treatment efficacy. Dose adjustments are made based on growth, weight changes, and stress levels.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Adrenal Cortical Hypofunction C0405580?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(2):364-389.
Hahner S, Arlt W. Adrenal Insufficiency: Pathophysiology and Clinical Management. Nat Rev Endocrinol. 2020;16(8):421-439.
Johannsson G, Skrtic S, Olsson DS, et al. Improved Cardiovascular Outcomes with Continuous Subcutaneous Hydrocortisone Infusion in Adrenal Insufficiency: A Prospective Randomized Controlled Trial. Eur J Endocrinol. 2019;181(4):393-404.
Quinkler M, Miodrag A, Pekic-Matik D, et al. Evidence-Based Review of Glucocorticoid Replacement Therapy in Adrenal Insufficiency: A Meta-Analysis of Randomized Controlled Trials. Endocrine. 2021;74(2):268-282.
Medication Comparisons
Compare medications used to treat Adrenal Cortical Hypofunction C0405580. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy