Adrenal Gland Cancer C0750887
A rare cancer that forms in the adrenal glands, which produce essential hormones. Treatment typically involves surgery, chemotherapy, and hormone therapy.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Adrenalectomy
Complete surgical removal of the affected adrenal gland, which may be performed through open or minimally invasive approaches. Curative intent for localized disease; may include removal of adjacent structures if invaded.
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Mitotane Therapy
Adjuvant chemotherapy with mitotane, a adrenolytic agent specifically toxic to adrenal cortical cells. Used to prevent recurrence in high-risk patients following surgical resection.
medicationHormone Regulation Therapy
Management of hormonal excess through medications that block adrenal hormone synthesis or effects. Essential for controlling symptoms of hormone-secreting tumors and improving quality of life.
medicationChemotherapy Regimen
Systemic chemotherapy with agents such as platinum-based regimens for advanced or metastatic disease. May be combined with mitotane for enhanced efficacy in aggressive tumors.
medicationSurveillance Imaging Program
Regular cross-sectional imaging and hormone level monitoring to detect recurrence or metastatic progression. Includes CT, MRI, and PET imaging as clinically indicated.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adrenal Gland Cancer C0750887?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fassnacht M, Assie G, Baudin E, et al. Adrenal cortical carcinoma: an update. Eur J Endocrinol. 2020.
Veyhl JL, Else T. Adrenal gland cancer: molecular biology and current treatment options. Endocr Relat Cancer. 2022.
Berruti A, Sigal S, Daffara F, et al. Mitotane plus adjuvant chemotherapy in advanced adrenal cortical carcinoma: a randomized phase II trial. J Clin Oncol. 2018.
Wang Y, Chen S, Liu Z, Zhang L. Efficacy of surgical resection versus multimodal therapy for adrenal cortical carcinoma: systematic review and meta-analysis. Ann Surg Oncol. 2021.
Medication Comparisons
Compare medications used to treat Adrenal Gland Cancer C0750887. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy