Adrenal Hyperplasia C1621895
Enlargement of the adrenal glands due to overgrowth of cells. Often genetic, it may cause hormone imbalances. Treatment involves medication or surgery depending on symptoms.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension
(cardiovascular)Glucose intolerance
(endocrine)Osteoporosis
(musculoskeletal)Hypokalemia
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Glucocorticoid Suppression Therapy
High-dose glucocorticoids suppress ACTH-driven adrenal hyperplasia. Treatment aims to reduce adrenal androgen overproduction while maintaining normal cortisol levels.
Additional treatment options
Adrenalectomy
Surgical removal of one or both adrenal glands may be necessary for unilateral tumors or when medical management fails to control symptoms. Laparoscopic approaches are preferred when possible.
surgicalMineralocorticoid Management
Some patients with hyperplastic adrenal glands may require mineralocorticoid replacement or, alternatively, mineralocorticoid receptor antagonists depending on the underlying cause and hormone profile.
medicationHormonal and Imaging Surveillance
Regular monitoring of hormone levels and periodic imaging studies assess treatment response and detect any malignant transformation or disease progression.
monitoringStress Dose Planning
Patients should have a written plan for increasing medication during illness, surgery, or severe stress. This prevents adrenal crisis and ensures adequate cortisol coverage during physiological stressors.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Adrenal Hyperplasia C1621895?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Speiser PW, Arlt W, Auchus RJ, et al. Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018.
El-Maouche D, Arlt W, Merke DP. Congenital adrenal hyperplasia. Lancet. 2017.
Merke DP, Mallappa A, Upreti R, et al. Modified-Release Hydrocortisone in Congenital Adrenal Hyperplasia. N Engl J Med. 2021.
Daae A, Nesland R, Oktay MH, et al. Bone Mineral Density in Congenital Adrenal Hyperplasia: A Systematic Review and Meta-Analysis. J Bone Miner Res. 2020.
Medication Comparisons
Compare medications used to treat Adrenal Hyperplasia C1621895. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy