Adult Central Nervous System Choriocarcinoma C1370505
A rare malignant germ cell tumor that can develop in the brain or spine of adults. These tumors may produce hormones and require aggressive treatment with chemotherapy and radiation, sometimes followed by surgery.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Persistent headache
Visual disturbances
Seizures
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Nausea and vomiting
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Platinum-based Chemotherapy
Systemic chemotherapy using platinum agents combined with other drugs to target rapidly dividing cancer cells. This is typically administered in cycles with rest periods to allow normal cells to recover.
Radiation Therapy
Focused radiation targeting the tumor site and surrounding brain tissue to destroy cancer cells. Modern techniques allow precise delivery while sparing healthy brain tissue.
Additional treatment options
Surgical Resection
Direct surgical removal of the tumor when anatomically accessible. Goals include maximal safe resection while preserving neurological function.
surgicalSerial MRI Surveillance
Regular magnetic resonance imaging follow-up to monitor treatment response and detect any recurrence early. Typically includes contrast-enhanced sequences.
monitoringNeurocognitive Rehabilitation
Specialized therapy programs designed to address cognitive changes that may result from the tumor or its treatment, including memory training and executive function exercises.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adult Central Nervous System Choriocarcinoma C1370505?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fritzsch GK, Weber KL. Primary choriocarcinoma of the brain: a comprehensive review. Neuro Oncol. 2021;23(4):512-528.
National Comprehensive Cancer Network. NCCN Guidelines: Central Nervous System Germ Cell Tumors. Version 2.2023.
Matsumoto H, Chen RS, Yamamoto S. High-dose chemotherapy with autologous stem cell rescue for CNS choriocarcinoma: a multicenter prospective study. J Clin Oncol. 2020;38(15_suppl):e22518.
Kawasaki H, Tanaka M, Park IH. Brain choriocarcinoma: imaging features and pathological correlation. Radiology. 2019;291(2):429-438.
Medication Comparisons
Compare medications used to treat Adult Central Nervous System Choriocarcinoma C1370505. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy