Adult Central Nervous System Primitive Neuroectodermal Neoplasm C1332196
An aggressive brain tumor made of primitive nerve cells. Rare in adults, more common in children. Requires aggressive treatment with surgery, radiation, and chemotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Headache
Seizure
Diplopia
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Nausea with vomiting
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Maximal Safe Resection
Aggressive surgical debulking when feasible remains a cornerstone treatment, aiming to remove the maximum safe amount of tumor tissue. Intraoperative mapping and monitoring help preserve critical neurological functions during resection.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Craniospinal Irradiation
Full craniospinal radiation with boost to the tumor bed is standard for adult PNETs. Treatment planning uses advanced techniques to conform radiation to target volumes while sparing normal brain and spinal cord tissue.
Additional treatment options
Adjuvant Chemotherapy
Multi-agent chemotherapy regimens, often including vincristine, lomustine, and cyclophosphamide, may be used adjuvantly. Treatment requires regular hematologic monitoring and supportive care for side effects.
medicationNeurorehabilitation
Comprehensive rehabilitation including physical, occupational, and speech therapy helps patients recover functional abilities affected by tumor or treatment. Programs are tailored to individual deficits and progressive goals.
physical_therapyPsycho-Oncology Support
Specialized psychological support addresses anxiety, depression, and adjustment challenges common in brain tumor patients. Interventions include individual therapy, support groups, and family counseling.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adult Central Nervous System Primitive Neuroectodermal Neoplasm C1332196?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Gajjar A, Packer RJ, Foreman NK, et al. CNS embryonal tumors in children younger than 3 years: a Children's Oncology Group study. Neuro-Oncology. 2018.
Ellison DW, Kocak M, Figarella-Branger D, et al. Histopathological and molecular heterogeneity in medulloblastoma and CNS primitive neuroectodermal tumors. J Neuropathol Exp Neurol. 2012.
Kline CN, Bond D, Weil RJ. Treatment outcomes in adult and pediatric CNS PNET: a systematic review and meta-analysis. J Clin Oncol. 2019.
Rusch A,決ONeill A, Bouffet E, et al. Refining the classification of central nervous system embryonal tumors: molecular insights and clinical implications. Lancet Oncol. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy