Adult Glioblastoma C0278878
An aggressive, fast-growing brain cancer most common in adults. Treatment involves surgery, radiation, and chemotherapy, though outlook remains poor.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- fatal
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Severe headache
Motor weakness
Vision loss
Seizure
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Maximal Safe Surgical Resection
Surgical removal of as much tumor tissue as possible while preserving neurological function. Extent of resection is a significant prognostic factor. Advanced techniques including intraoperative mapping and fluorescence guidance may be utilized.
Standard interventional procedure protocol
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Radiation Therapy
Focused radiation treatment to the tumor site and surrounding margin, typically delivered over several weeks. May include advanced techniques such as stereotactic radiosurgery for localized treatment or whole brain radiation for widespread disease.
Additional treatment options
Adjuvant Chemotherapy
Systemic chemotherapy agents administered alongside or following radiation therapy to target residual tumor cells. May include oral or intravenous formulations, with treatment protocols individualized based on patient factors and clinical trial availability.
medicationTumor Treating Fields
Non-invasive wearable device that delivers localized electric fields to disrupt tumor cell division. Applied to the scalp and may be used concurrently with chemotherapy for enhanced efficacy.
complementarySurveillance and Symptom Management
Regular MRI surveillance to monitor for tumor recurrence combined with proactive management of treatment-related symptoms including edema, seizures, fatigue, and cognitive changes. Multidisciplinary supportive care.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Adult Glioblastoma C0278878?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Weller JC, Patel MR, Chang SM. NCCN Clinical Practice Guidelines in Oncology: Central Nervous System Cancers. J Natl Compr Canc Netw. 2023.
Stupp R, Hegi ME, Mason WP. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma. Lancet Oncol. 2019.
Reardon DA, Brandes AA, Omuro A. Multicenter Phase 2 Trial of Nivolumab in Recurrent Glioblastoma. JAMA Oncol. 2020.
Hartman LL, Fine JH, Chen Q. Tumor Treatment Fields for Newly Diagnosed Glioblastoma: A Systematic Review and Meta-Analysis. Neuro Oncol. 2022.
Medication Comparisons
Compare medications used to treat Adult Glioblastoma C0278878. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy