Adult Hepatocellular Carcinoma C0279607
The most common type of primary liver cancer in adults, often linked to underlying liver disease such as cirrhosis or hepatitis. Treatment options include surgery, ablation, and targeted therapies. Prognosis depends on disease stage and liver function.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hemoptysis
Abdominal pain (right upper quadrant)
(gastrointestinal)Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Fatigue
(general)Jaundice
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Surgical Resection
Partial hepatectomy to remove the tumor and surrounding liver tissue when technically feasible and liver function permits. Offers potential cure for early-stage hepatocellular carcinoma.
Liver Transplantation
Total replacement of the diseased liver with a healthy donor liver, addressing both the cancer and underlying cirrhosis. Reserved for patients meeting specific criteria for tumor size and number.
Additional treatment options
Transarterial Chemoembolization
Locally delivered chemotherapy combined with arterial embolization to starve the tumor of blood supply while delivering high-dose cytotoxic agents directly to the cancer.
procedureTargeted Systemic Therapy
Oral targeted agents that inhibit tumor angiogenesis and growth pathways, used for advanced hepatocellular carcinoma when surgical options are not feasible.
medicationAblation Therapies
Image-guided procedures using radiofrequency, microwave, or cryoablation to destroy tumors through thermal or freezing techniques, particularly for smaller tumors or patients unsuitable for surgery.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adult Hepatocellular Carcinoma C0279607?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, et al. AASLD Guidelines for the Treatment of Hepatocellular Carcinoma. Hepatology. 2018;67(1):358-380.
Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, et al. Hepatocellular Carcinoma. Nat Rev Dis Primers. 2021;7(1):6.
Vogel A, Martinelli E, Chandrasekar V, Finn RS, Galle PR, Ducreux M, et al. Updated Treatment Approaches for Hepatocellular Carcinoma: A Meta-Analysis of Systemic Therapies. Ann Oncol. 2022;33(8):766-779.
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, et al. Lenvatinib versus Sorafenib in First-Line Treatment of Patients with Unresectable Hepatocellular Carcinoma: A Randomised Phase 3 Non-Inferiority Trial. Lancet. 2018;391(10126):1163-1173.
Medication Comparisons
Compare medications used to treat Adult Hepatocellular Carcinoma C0279607. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy