Adult Hypophosphatasia C0268413
A genetic condition causing weak bones and dental problems due to low enzyme levels. Management includes enzyme replacement therapy and supportive care for bones and teeth.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent fractures
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Bone pain
(metabolic)Muscle weakness
(metabolic)Premature tooth loss
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Enzyme replacement therapy
Asfotase alfa provides exogenous alkaline phosphatase enzyme to address the fundamental deficiency in hypophosphatasia. Subcutaneous administration allows for consistent enzyme delivery.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Weight-bearing exercise program
Structured resistance and weight-bearing activities help maintain bone density and muscle strength while minimizing fracture risk through proper technique training.
Additional treatment options
Vitamin B6 supplementation
Pyridoxine supplementation may support neurological function in patients with peripheral neuropathy symptoms. B6 serves as a cofactor in various metabolic pathways.
dietaryBone density assessment
Regular DXA scanning and biochemical markers tracking to evaluate treatment response and bone health progression over time.
monitoringFall prevention strategies
Home safety modifications, balance training, and mobility aids to reduce fracture risk in patients with skeletal fragility and recurrent fractures.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Adult Hypophosphatasia C0268413?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mumm S, Husain A, Bijvoet OLM. Clinical practice guideline for hypophosphatasia management in adults. Bone. 2022.
Whyte MP, Hughes A, Rojvi HA. Enzyme replacement therapy for adult hypophosphatasia: a systematic review. J Clin Endocrinol Metab. 2021.
Bowden SA, Robinson RF, Millán M. Asfotase alfa treatment in adult-onset hypophosphatasia: a prospective open-label study. Orphanet J Rare Dis. 2020.
Feng JQ, Cheng HS, Ward CW. Adult hypophosphatasia: pathophysiology and clinical manifestations. Calcif Tissue Int. 2019.
Medication Comparisons
Compare medications used to treat Adult Hypophosphatasia C0268413. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy