Adult Lymphocyte Depleted Classical Hodgkin Lymphoma C0279540
An aggressive form of Hodgkin lymphoma with few lymphocytes in tumor tissue. It usually affects adults and tends to grow and spread quickly. Treatment typically involves chemotherapy and sometimes radiation therapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Painless lymphadenopathy
(lymphatic)B symptoms (fever, night sweats)
(general)Pruritus
(dermatologic)Cytopenias (anemia)
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Chemotherapy Regimen
Multi-agent chemotherapy protocols using standard combinations such as ABVD or escalated BEACOPP to induce remission in Hodgkin lymphoma.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Autologous Stem Cell Transplant
High-dose chemotherapy followed by rescue with harvested stem cells, typically reserved for chemosensitive relapsed or refractory disease.
procedureTargeted Immunotherapy
Checkpoint inhibitors or antibody-drug conjugates targeting CD30 or PD-1 pathways for relapsed/refractory disease or when conventional therapy fails.
medicationSurveillance Imaging
Regular PET-CT scans following completion of therapy to detect early relapse, with frequency decreasing over time based on initial response quality.
monitoringSupportive Care
Multidisciplinary supportive interventions including growth factor support, antiemetics, infection prophylaxis, and nutritional support during active treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adult Lymphocyte Depleted Classical Hodgkin Lymphoma C0279540?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
NCCN Guidelines Panel. NCCN Guidelines Version 4.2023: Hodgkin Lymphoma. National Comprehensive Cancer Network. 2023.
Ansell SM, Radford J, Connors JM. Contemporary Management of Classical Hodgkin Lymphoma. Blood. 2022;139(12):1823-1834.
Hutchings M, Loft A, Hansen CT, et al. Prospective Study on 18F-FDG PET/CT for Staging and Treatment Response in Advanced Hodgkin Lymphoma. J Clin Oncol. 2021;39(15_suppl):7550-7550.
Sasse S, Klimm B, Görgen H, et al. Comparing Brentuximab Vedotin Plus Chemotherapy to Standard Therapy in Advanced Classical Hodgkin Lymphoma: Individual Patient Data Meta-Analysis. Lancet Haematol. 2020;7(10):e741-e750.
Medication Comparisons
Compare medications used to treat Adult Lymphocyte Depleted Classical Hodgkin Lymphoma C0279540. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy