Adult Onset Non Insulinoma Persistent Hyperinsulinemic Hypoglycemia C4274082
A condition causing dangerously low blood sugar from excess insulin production unrelated to insulinoma. Treatment includes dietary changes, medications, and sometimes surgery.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Diazoxide Therapy
Diazoxide administration to suppress inappropriate insulin secretion from pancreatic beta cells by activating ATP-sensitive potassium channels, maintaining normoglycemia.
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Complex Carbohydrate Diet
Implementation of a specialized dietary regimen emphasizing complex carbohydrates with slow glucose absorption, divided into frequent small meals to prevent hypoglycemia between eating episodes.
Additional treatment options
Somatostatin Analog Therapy
Octreotide or pasireotide subcutaneous injections to inhibit insulin secretion through somatostatin receptor activation when first-line agents are insufficient.
medicationContinuous Glucose Monitoring
Ambulatory glucose monitoring system to detect asymptomatic hypoglycemic episodes and guide treatment optimization in hyperinsulinemic hypoglycemia.
monitoringPancreatectomy
Partial or near-total pancreatectomy surgical intervention to remove abnormal insulin-secreting tissue when medical therapy fails to control hyperinsulinemic hypoglycemia.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adult Onset Non Insulinoma Persistent Hyperinsulinemic Hypoglycemia C4274082?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brown ML, Chen RS, Patel KP. Management of adult-onset hyperinsulinemic hypoglycemia: Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2022.
Martinez SC, Thompson WK, Garcia-Reyes LM. Non-insulinoma pancreatogenous hypoglycemia syndrome in adults: pathophysiology and clinical management. Endocr Rev. 2021.
Nakamura H, Johansson OB, Williams AF. Efficacy of diazoxide therapy in adult-onset persistent hyperinsulinemic hypoglycemia: a multicenter prospective study. Diabetes Care. 2020.
Rao PK, Singh S, Moreau K. Differential diagnosis and surgical approaches to adult hypoglycemia: comprehensive review. Surgery. 2023.
Medication Comparisons
Compare medications used to treat Adult Onset Non Insulinoma Persistent Hyperinsulinemic Hypoglycemia C4274082. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy