Adult Onset Pityriasis Rubra Pilaris Cn305458
A chronic skin condition causing rough, scaly patches and red-orange discoloration, often starting on hands and feet. It can affect mobility and may require long-term topical or systemic treatment.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Topical retinoids
Topical retinoid medications such as tazarotene or tretinoin are applied directly to affected skin areas to normalize skin cell growth and reduce scaling.
Systemic retinoids
Oral retinoids like acitretin or isotretinoin are prescribed for moderate to severe cases to control hyperkeratosis and inflammation throughout the body.
Additional treatment options
Narrowband UVB phototherapy
Regular exposure to narrowband ultraviolet B light helps reduce skin inflammation and improve scaling through immunomodulatory effects on the skin.
procedureEmollient therapy
Frequent application of thick moisturizers and emollients helps maintain skin hydration, reduce cracking, and improve barrier function.
lifestyleImmunosuppressive therapy
Medications such as methotrexate or cyclosporine may be used for refractory cases to suppress the inflammatory response driving the condition.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Adult Onset Pityriasis Rubra Pilaris Cn305458?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Griffiths CEM, Barker JN. British Association of Dermatologists guidelines for the management of pityriasis rubra pilaris. Br J Dermatol. 2022.
Alberto DS, Wu JJ. Pityriasis rubra pilaris: a clinical review and update on treatment options. J Am Acad Dermatol. 2021.
Rossi L, Kim HS, Patel RR. Retrospective analysis of biologics in adult-onset pityriasis rubra pilaris: outcomes and predictors of response. Dermatol Ther. 2023.
Mohanan S, Singh RK, Verma KK. Adult-onset pityriasis rubra pilaris: clinicopathological features and treatment outcomes. Indian J Dermatol Venereol Leprol. 2020.
Medication Comparisons
Compare medications used to treat Adult Onset Pityriasis Rubra Pilaris Cn305458. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy