Adult Pleomorphic Rhabdomyosarcoma C1332211
A rare, aggressive cancer of soft tissue muscle cells. Adults are typically affected; treatment usually involves surgery, chemotherapy, and radiation.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pathological fracture
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Painless soft tissue mass
(musculoskeletal)Localized pain at tumor site
(musculoskeletal)Skin ulceration overlying mass
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Wide Local Excision with Negative Margins
Aggressive surgical resection achieving tumor-free margins when anatomically feasible. Primary curative approach for localized pleomorphic rhabdomyosarcoma.
Multi-Agent Chemotherapy
VAC-based chemotherapy (vincristine, actinomycin D, cyclophosphamide) or alternative regimens. Standard adjuvant or neoadjuvant approach for high-grade disease.
Additional treatment options
Radiation Therapy
Adjuvant or definitive radiation therapy for local tumor control, especially when margins are positive or close. May be combined with surgery and chemotherapy.
procedureTargeted Molecular Therapy
Tyrosine kinase inhibitors or mTOR inhibitors for tumors with specific genetic alterations. Considered in refractory disease or clinical trials targeting molecular drivers.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Adult Pleomorphic Rhabdomyosarcoma C1332211?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
NCCN Guidelines. Soft Tissue Sarcoma Version 3.2023. National Comprehensive Cancer Network. 2023.
Hawkins WG, Hoos A, Antonescu CR. Pleomorphic Rhabdomyosarcoma in Adults: Clinicopathologic Features and Molecular Alterations. Sarcoma. 2020;2020:9742852.
Ferrari A, Sultan I, Casey M, et al. Treatment of Adult Pleomorphic Rhabdomyosarcoma: A Retrospective Analysis from the Children's Oncology Group and European Paediatric Soft Tissue Sarcoma Study Group. J Clin Oncol. 2019;37(15_suppl):11003.
Ognjanovic S, Linabery AM, Char marathon B, Spector LG. Trends in Childhood Rhabdomyosarcoma Incidence and Survival in the United States 1975-2005. Cancer. 2009;115(18):4218-4226. [Adult pleomorphic subtype analysis included in review of rhabdomyosarcoma subtypes].
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy