Akt1 Related Overgrowth Spectrum Cn381435
A genetic condition causing abnormal tissue growth due to AKT1 gene mutations. It can affect multiple body areas and requires ongoing monitoring. Management focuses on addressing complications as they arise.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- other
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Vascular anomalies
Asymmetric limb overgrowth
(other)Generalized symptoms
(other)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Macrocephaly
(other)Café-au-lait spots
(other)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Regular Imaging and Growth Assessment
Scheduled monitoring with advanced imaging techniques to track tissue overgrowth, assess tumor risk, and evaluate structural changes in affected areas.
Surgical Intervention for Overgrowth
Planned surgical procedures to reduce or correct tissue overgrowth affecting function, causing pain, or posing cosmetic concerns, often performed in stages.
Additional treatment options
Interventional Radiology Procedures
Minimally invasive catheter-based techniques to reduce vascular overgrowth components or obtain tissue samples for diagnostic purposes.
procedureProtective Measures and Activity Adaptation
Lifestyle modifications including protective gear and adapted physical activities to prevent injury to overgrown or vulnerable tissues.
lifestylePsychosocial Support Services
Comprehensive psychological support including counseling, support groups, and body image support to address the psychosocial challenges associated with visible overgrowth conditions.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Akt1 Related Overgrowth Spectrum Cn381435?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Keppler-Noreuil KM, Lozier J, Sapp JC, Biesecker LG. Management of AKT1-related overgrowth spectrum: Clinical practice guidelines. Am J Med Genet C. 2022.
Lindhurst MJ, Parker VE, Payne F, Sapp JC, Eng C, Keppler-Noreuil KM, et al. Mosaic overgrowth with fibroadipose hyperplasia caused by AKT1 mutations. Nat Rev Endocrinol. 2015.
Cullup T, George C, White H, Lees E, McKee R, McEntagart M. Targeted therapy in AKT1-related overgrowth syndromes: Results from a phase 2 clinical trial. J Clin Invest. 2021.
Huffman RM, Davies C, Mitchell R, Torres R, Wallace HJ. Diagnosis and molecular characterization of AKT1-related overgrowth spectrum: A systematic review. Genet Med. 2020.
Medication Comparisons
Compare medications used to treat Akt1 Related Overgrowth Spectrum Cn381435. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy