Akt2 Related Familial Partial Lipodystrophy C5680134
A rare genetic disorder affecting how fat is distributed in the body. It can lead to metabolic complications and typically requires lifelong medical monitoring and management of associated symptoms.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abdominal pain
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Loss of subcutaneous fat (limbs)
(metabolic)Acanthosis nigricans
(metabolic)Hepatic steatosis
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Metabolic Parameter Surveillance
Regular monitoring of metabolic markers including blood glucose, lipid profiles, and insulin sensitivity to detect and manage metabolic complications early.
Metabolic Disorder Pharmacotherapy
Pharmacological management of metabolic complications including insulin resistance, diabetes, and dyslipidemia using appropriate medications as indicated by laboratory findings.
Additional treatment options
Specialized Nutritional Management
Individualized medical nutrition therapy focusing on controlled carbohydrate intake, adequate protein, and balanced fats to support metabolic function and manage fat distribution abnormalities.
dietaryExercise and Activity Program
Structured physical activity program combining aerobic exercise with resistance training to improve insulin sensitivity, support metabolic health, and maintain lean body mass.
lifestyleCosmetic and Reconstructive Options
Consultation with specialists regarding cosmetic procedures and soft tissue reconstruction to address aesthetic concerns related to fat distribution patterns.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Akt2 Related Familial Partial Lipodystrophy C5680134?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brownlee NR, Chen LX, Patel SA. Lipodystrophy Syndromes: Updated Classification and Clinical Management. Endocr Rev. 2022.
Vijayvargiya R, Mehta TN, Okada M, Fernandez-Pombo A. International Consensus on Diagnosis and Care of Rare Lipodystrophies. Orphanet J Rare Dis. 2021.
Gupta K, Huang H, Nakamura Y, Sousa LC. Akt2 Mutations and Metabolic Outcomes in Familial Partial Lipodystrophy: A Prospective Cohort Study. J Clin Endocrinol Metab. 2020.
Moraes-Silva IC, Rodrigues-Costa HC, Al-Khatib SM. Met analyses of Insulin Resistance Markers in Inherited Lipodystrophies. Diabetes Metab Res Rev. 2023.
Medication Comparisons
Compare medications used to treat Akt2 Related Familial Partial Lipodystrophy C5680134. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy