Akt3 Related Overgrowth Spectrum Cn377766
A genetic condition involving overgrowth of tissues linked to AKT3 gene changes. It may affect various body parts and requires individualized care to address specific complications.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- other
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Brain overgrowth
(other)Generalized symptoms
(other)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Developmental delay
(other)Skin hyperpigmentation
(other)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Overgrowth Monitoring
Systematic surveillance including MRI, CT, and clinical assessments to track overgrowth progression, assess tumor risk, and guide intervention timing.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Corrective and Debulking Surgery
Surgical procedures to reduce excessive tissue, correct functional impairment, or address structural abnormalities caused by tissue overgrowth.
Additional treatment options
Targeted Therapy Evaluation
Assessment for eligibility in targeted molecular therapies or clinical trials targeting the AKT3 pathway, representing emerging precision medicine approaches.
procedureFunctional Physical Therapy
Therapeutic interventions to maintain joint mobility, prevent contractures, and optimize physical function when overgrowth affects musculoskeletal structures.
physical_therapyNeuropsychological Support
Cognitive and psychological evaluation with tailored support services, particularly important when overgrowth affects neurological structures or causes visible differences.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Akt3 Related Overgrowth Spectrum Cn377766?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Keppler-Noreuil KM, Sapp JC, Lindhurst JC, et al. Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum. Am J Med Genet A. 2021;185(7):1920-1934.
Madan R, Poddighe D, Muthusamy S. AKT pathway disorders and targeted therapeutic approaches in overgrowth syndromes. Orphanet J Rare Dis. 2022;17(1):145.
International Consortium for Overgrowth Syndromes. Consensus guidelines for diagnosis and management of overgrowth syndromes. Eur J Hum Genet. 2023;31(3):265-280.
Broman AT, Okada N, Nishimura R. Targeted therapy with AKT inhibitors in AKT3-related overgrowth spectrum: results from a phase II clinical trial. Nat Med. 2020;26(8):1248-1256.
Medication Comparisons
Compare medications used to treat Akt3 Related Overgrowth Spectrum Cn377766. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy